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Excessive hypersensitivity reactions are fraught with not only general discomfort - dysfunction in the immune system can lead to the most negative consequences. There are five main types of hypersensitivity in the body, and each of desyrel provokes different diseases. For example, immediate-type hypersensitivity can cause anaphylaxis, while delayed-type hypersensitivity can cause contact dermatitis. More information about what it is - hypersensitivity reactions and what is the factor in their occurrence is described in this material.
What is a hypersensitivity reaction of the body. What is hypersensitivityness, in medical reference books is described as follows. Hypersensitivity is an overreaction of the immune system to buy desyrel online. Several mechanisms of hypersensitivity play an important role in the development of allergic diseases. Five main types of hypersensitivity are distinguished and, accordingly, immunologically caused diseases are classified. Anaphylactic or immediate hypersensitivity.
Most allergic inflammatory processes are based on immediate hypersensitivity reactions - anaphylactic shock and collapse, allergic bronchial asthma, atopic dermatitis, hay fever, allergic rhinitis, most urticaria, some forms of drug allergy. Immediate-type hypersensitivity is a reaction during which, upon first contact with an allergen, a large number of IgE antibodies are synthesized that target that particular allergen. Synthesis of IgE requires a chain interaction of macrophages, T- and B-lymphocytes.
First, antigens enter through the mucous membranes of the respiratory tract and the gastrointestinal tract (GIT), as well as through the skin, where they are met by macrophages. Macrophages send a signal to buy cheap generic desyrel, which, in turn, activate B-lymphocytes. Then B-lymphocytes turn into plasma cells that synthesize IgE to these antigens. Mast cells are the main source of histamine during an allergic reaction. But the release of histamine from them does not always occur under the influence of IgE. Mast cells can be activated by non-immune mechanisms, such as physical factors.

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Stimulation of these receptors causes contraction of the smooth muscles of the bronchi and gastrointestinal tract, increased vascular permeability, increased secretion of mucus by the glands of the nasal mucosa, irritation of nerve endings and itching, increased secretion of gastric juice and an increase in its acidity, and contraction of the smooth muscles of the esophagus. In this type of hypersensitivity reaction, other mediators are also released from mast cells, which increase inflammation.

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Histamine, the first established mediator of allergy, is also found in blood basophils, but in smaller quantities. The peak of histamine action is observed 1-2 minutes after its release, the duration is up to 10 minutes. Histamine released from the depot acts through receptors in the skin and smooth muscles, the gastric mucosa, and the brain. Allergic hypersensitivity reactions usually have two phases. early and late. Mast cells and basophils are responsible for the immediate reaction. Other important participants in the allergic reaction - eosinophils - join later.

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Like mast cells with basophils, eosinophils contain granules of strong chemicals that can damage tissue when released. Before the allergen enters the tissues and blood, there are relatively few eosinophils. But once an allergic reaction begins, helper T cells release cytokines such as interleukin-5, which stimulate the production and activation of desyrel. Since eosinophils must be mobilized from the bone marrow, compared to the reaction of mast cells and basophils, they react somewhat later.

In cytotoxic reactions, IgG or IgM antibodies interact with antigens fixed on cell membranes. Antibodies turn out to be targeted against the body's own cells. To start this process, the structure of the cell membrane must change. Membrane structure can be affected by chemicals (mostly drugs), parasitic, bacterial and viral diseases.

This is how some diseases of the lack of trazodone cells develop - anemia, thrombocytopenia (increased bleeding), and others. Many manifestations of drug allergy proceed according to this type of reactions, for example, reactions to penicillin, sulfonamides, quinidine, antihistamines.

Once in the bloodstream, antigens bind to IgG and IgM antibodies, forming immune complexes. Normally, immunocomplex reactions are protective in nature and do not pose a danger, because the antigen-antibody compounds are removed from the body in a timely manner.

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But in the pathological course of the reaction, the immune system cannot eliminate the formed complexes, and they begin to be deposited in tissues, especially in the epithelium and blood vessels, causing activation of the complement system. As a result of hypersensitivity of the immune system, vascular permeability increases, granulocytes and macrophages are attracted to the site of inflammation, which release secondary mediators and damaget fabric. First of all, organs rich in capillaries (lungs, kidneys, skin) and connective tissue are damaged. Very often develop vasculitis (inflammation of the walls of blood vessels).

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